AMCAS FL 2 #23

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AMCAS FL 2 #23

Post by chibean » Thu May 28, 2020 10:21 pm

For this question:

Based on the data presented in figures 2 and 3, what is the most likely role of Y229 in protein stability and cAMP activation?

I did not interpret the graphs the right way, so how would I know from the passage that the variants showed they were being removed? I thought it was showing the variant by itself and the effects.
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Re: AMCAS FL 2 #23

Post by NS_Tutor_Mathias » Fri May 29, 2020 3:02 am

AMCAS asks science questions now? That is hardcore ;)

(Since this relates to what is giving you trouble in this question, I do want to emphasize that reading every single character in a figure, graph or passage can be very helpful for the MCAT. As you make a habit of paying attention to details, the notation will start making a bit more sense!)

The problem you are having is not being familiar with the shorthand notation for amino acid substitutions. Y229A means "Replace tyrosine residue at position #229 with alanine". This is very common notation on the MCAT. Both figures talk about this 'Y229A' replacement.
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